JI051

JI051是一种Hes1-PHB2相互作用稳定剂，能够与癌症相关蛋白伴侣prohibitin2(PHB2)相互作用，通过抑制Notch下游效应基因Hes1来诱导细胞周期停滞。具有抗肿瘤作用。

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库存: 现货

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数量
5mg

￥2400.00

1920.00

- +
10mg

￥3487.00

2790.00

- +
50mg

￥7012.00

5610.00

- +
100mg

￥12287.00

9830.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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Background

JI051 is a stabilizer for the Hes1-PHB2 interaction, interacts with a cancer-associated protein chaperone prohibitin 2 (PHB2), induces cell-cycle arrest by inhibiting the Notch downstream effector gene Hes1. Anti-cancer activity[1].

JI051 causes G2/M cell-cycle arrest[1].JI051 (0.1-10 µM, 24 hours) significantly inhibits cell proliferation of HEK293 cells, with an EC50 of 0.3 μM[1]. Cell Proliferation Assay[1] Cell Line: HEK293 cells

[1]. Perron A, et al. Small-molecule screening yields a compound that inhibits the cancer-associated transcription factor Hes1 via the PHB2 chaperone. J Biol Chem. 2018 May 25;293(21):8285-8294.