ML230

An inhibitor of ABCG2

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2mg

￥1212.00

970.00

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5mg

￥2287.00

1830.00

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Background

ML-230 is an inhibitor of ATP-binding cassette family G member 2 (ABCG2).¹ It selectively inhibits JC-1 efflux in Ig-MXP3 cells overexpressing ABCG2 over Jurkat cells overexpressing ABCB1 (IC₅₀s = 0.13 and 4.65 ?M, respectively). ML-230 enhances inhibition of IGROV-1/T8 ovarian cancer cell colony formation induced by topotecan .² Intratumoral injection of ML-230 (100 nM) and topotecan reduces tumor size in an IGROV-1/T8 mouse xenograft model.

1.Strouse, J.J., Ivnitski-Steele, I., Khawaja, H.M., et al.A selective ATP-binding cassette subfamily G member 2 efflux inhibitor revealed via high-throughput flow cytometryJ. Biomol. Screen.18(1)26-38(2013) 2.Ricci, J.W., Lovato, D.M., Severns, V., et al.Novel ABCG2 antagonists reverse topotecan-mediated chemotherapeutic resistance in ovarian carcinoma xenograftsMol. Cancer Ther.15(12)2853-2862(2016)