NU6140

A Cdk2 inhibitor

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5mg

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1040.00

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货号: ajce53626
CAS: 444723-13-1
别名:
分子式: C23H30N6O2
分子量: 422.52
纯度: >98%
溶解度: DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/ml
储存: Store at -20°C
库存: 现货

Background

NU 6140 is a cyclin-dependent kinase 2 (Cdk2) inhibitor (IC₅₀ = 0.41 μM) that demonstrates 10- to 36-fold selectivity against Cdk2-cyclin A compared to Cdk1-cyclin B, Cdk4-cyclin D, Cdk5-p25, or Cdk7-cyclin H.¹ NU 6140 has been found to induce cell-cycle arrest at the G₂-M phase and to potentiate the apoptotic effect of paclitaxel in HeLa cells by inhibiting the anti-apoptotic protein, survivin.¹

1.Pennati, M., Campbell, A.J., Curto, M., et al.Potentiation of paclitaxel-induced apoptosis by the novel cyclin-dependent kinase inhibitor NU6140: A possible role for survivin down-regulationMol. Cancer Ther.4(9)1328-1337(2005)