Sakuranetin

A flavonoid with diverse biological activities

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5mg

￥1212.00

970.00

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10mg

￥1625.00

1300.00

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Background

Sakuranetin is a flavonoid and phytoalexin that has been found in rice and has diverse biological activities.^1,2,3,4 It reduces blast fungus mycelium growth in vitro and decreases the number of fungal lesions and fungal DNA in blast fungus-infected rice leaves when applied at concentrations of 0.1 and 0.2 mM.¹ Sakuranetin is active against M. luteus and B. subtilis (MICs = 2 and 0.5 ?g/ml, respectively).² It is cytotoxic to KB nasopharyngal carcinoma cells (EC₅₀ = 10 ?g/ml). Sakuranetin (20 mg/kg) reduces alveolar enlargement, collagen and elastic fiber deposition, and bronchoalveolar lavage fluid (BALF) levels of TNF-α, IL-1β, and M-CSF in a mouse model of elastase-induced emphysema.³ It also reduces collagen fiber deposition and lung inflammation in a mouse model of LPS-induced acute lung injury.⁴

1.Hasegawa, M., Mitsuhara, I., Seo, S., et al.Analysis on blast fungus-responsive characters of a flavonoid phytoalexin sakuranetin; accumulation in infected rice leaves, antifungal activity and detoxification by fungusMolecules19(8)11404-11418(2014) 2.Orjala, J., Wright, A.D., Behrends, H., et al.Cytotoxic and antibacterial dihydrochalcones from Piper aduncumJ. Nat. Prod.57(1)18-26(1994) 3.Taguchi, L., Pinheiro, N.M., Olivo, C.R., et al.A flavanone from Baccharis retusa (Asteraceae) prevents elastase-induced emphysema in mice by regulating NF-κB, oxidative stress and metalloproteinasesRespir. Res.16(79)1-15(2015) 4.Bittencourt-Mernak, M.I., Pinheiro, N.M., Santana, F.P., et al.Prophylactic and therapeutic treatment with the flavonone sakuranetin ameliorates LPS-induced acute lung injuryAm. J. Physiol. Lung Cell Mol. Physiol.312(2)L217-L230(2017)