Sarolaner

An isoxazoline ectoparasiticide

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库存: 现货

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5mg

￥1625.00

1300.00

- +
10mg

￥2725.00

2180.00

- +
50mg

￥9175.00

7340.00

- +
100mg

￥16025.00

12820.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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货号: ajce53790
CAS: 1398609-39-6
别名: 1-[5'-[(5S)-5-(3,5-二氯-4-氟苯基)-4,5-二氢-5-(三氟甲基)-3-异恶唑基]螺[氮杂环丁烷-3,1'(3'H)-异苯并呋喃]-1-基]-2-(甲基磺酰基)乙酮,PF-6450567
分子式: C23H18Cl2F4N2O5S
分子量: 581.36
纯度: >98%
溶解度: DMSO : 150 mg/mL (258.02 mM);Water : < 0.1 mg/mL (insoluble)
储存: Store at 4°C, sealed storage, away from moisture
库存: 现货

Background

Sarolaner is an isoxazoline ectoparasiticide.¹ It inhibits GABA-induced chloride currents in CHO-K1 cells expressing either the gene for susceptible C. felis flea resistance-to-dieldrin subunits containing alanine at residue 285 (CfRDL-A285; IC₅₀ = 135 nM) or the gene for CfRDL subunits containing the alanine-to-serine resistance mutation (CfRDL-S285; IC₅₀ = 136 nM). It induces mortality in C. felis fleas (LC₈₀ = 0.3 ?g/ml) and O. turicata soft ticks (LC₁₀₀ = 0.003 ?g/ml). Sarolaner (2.5 mg/kg) eliminates live C. felis fleas, as well as R. sanguineus, I. ricinus, and D. reticulatus ticks, on dogs after 48 hours and reduces the number of fleas and ticks for at least 35 days. Formulations containing sarolaner have been used in the treatment and control of flea and tick infestations in dogs.

1.McTier, T.L., Chubb, N., Curtis, M.P., et al.Discovery of sarolaner: A novel, orally administered, broad-spectrum, isoxazoline ectoparasiticide for dogsVet. Parasitol.2223-11(2016)