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  • Tat-NR2B9c TFA
Tat-NR2B9c TFA的可视化放大

Tat-NR2B9c TFA

Tat-NR2B9c(TFA)是由20个氨基酸组成的多肽,为PSD-95的抑制剂,对PSD-95d2和PSD-95d1的EC50值分别为6.7nM和670nM。Tat-NR2B9c同时可降低NMDA诱导的p38的活化,具有神经保护作用。

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Tat-NR2B9c TFA的二维码
  • 库存: 现货
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  • 包装
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    促销价
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  • 1mg
    ¥762.00
    610.00
    - +
  • 5mg
    ¥1962.00
    1570.00
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  • 10mg
    ¥3050.00
    2440.00
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  • 25mg
    ¥5937.00
    4750.00
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  • 货号: ajce53898
  • CAS: 1834571-04-8
  • 别名: Tat-NR2Bct TFA; NA-1 TFA
  • 分子式: C107H189F3N42O32
  • 分子量: 2632.9
  • 纯度: >98%
  • 溶解度: Water : ≥ 50 mg/mL (18.99 mM)
  • 储存: Store at -20°C
  • 库存: 现货

Background

Tat-NR2B9c (TFA) is a 20-aa peptide, which acts as a postsynaptic density-95 (PSD-95) inhibitor, with an EC50 of 6.7 nM for PSD-95d2 (PSD-95 PDZ domain 2), and 670 nM for PSD-95d1[1]. Tat-NR2B9c also reduces NMDA-induced p38 activation, and possesses neuroprotective efficacy[2]. EC50: 6.7 nM (PSD-95d2), 670 nM (PSD-95d1)[1]p38[2]



[1]. Cui H, et al. PDZ protein interactions underlying NMDA receptor-mediated excitotoxicity and neuroprotection by PSD-95 inhibitors. J Neurosci. 2007 Sep 12;27(37):9901-15. [2]. Fan J, et al. P38 MAPK is involved in enhanced NMDA receptor-dependent excitotoxicity in YAC transgenic mouse model of Huntington disease. Neurobiol Dis. 2012 Mar;45(3):999-1009.

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