MW-150 dihydrochloride dihydrate

An inhibitor of p38α MAPK

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库存: 现货

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5mg

￥3775.00

3020.00

- +
10mg

￥5937.00

4750.00

- +
50mg

￥17625.00

14100.00

- +
100mg

￥28312.00

22650.00

- +

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货号: ajce54078
CAS: 1661020-92-3
别名: MW01-18-150SRM dihydrochloride dihydrate
分子式: C24H29Cl2N5O2
分子量: 490.43
纯度: >98%
溶解度: DMSO : 20.83 mg/mL (42.47 mM)
储存: Store at -20°C
库存: 现货

Background

MW-150 is an inhibitor of p38α MAPK (K_i = 101 nM).¹ It is 6-, 10-, and 14-fold selective for p38α MAPK over the serine/threonine protein kinase NLK, p38β MAPK, and p38δ MAPK, respectively, and is also selective over the enzymatically normal mutant p38α MAPK^T106M. It inhibits p38α MAPK phosphorylation of the endogenous substrate MAPK-activated protein kinase 2 (MK2) in LPS-activated glia in a concentration-dependent manner and decreases the levels of IL-1β in the same cells. MW-150 (2.5 mg/kg per day, i.p.) reduces the number of errors made in the spatial reference memory version of the radial arm water maze in aged amyloid precursor protein/presenilin 1 (APP/PS1) knock-in mice as a model of Alzheimer’s disease.

1.Roy, S.M., Grum-Tokars, V.L., Schavocky, J.P., et al.Targeting human central nervous system protein kinases: An isoform selective p38αMAPK inhibitor that attenuates disease progression in Alzheimer's disease mouse modelsACS Chem. Neurosci.6(4)666-680(2015)