UAMC-3203 hydrochloride

A ferroptosis inhibitor

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库存: 现货

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5mg

￥862.00

690.00

- +
10mg

￥1412.00

1130.00

- +
50mg

￥2287.00

1830.00

- +
100mg

￥3212.00

2570.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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Background

UAMC-3203 is an inhibitor of ferroptosis that has an IC₅₀ value of 10 nM for inhibition of erastin-induced ferroptosis in IMR-32 neuroblastoma cells.¹ It decreases iron-induced plasma lactate dehydrogenase (LDH) levels in a mouse model of acute iron poisoning when administered at a dose of 20 ?mol/kg. It is not toxic to mice following chronic administration of a 20 ?mol/kg dose for four weeks. UAMC-3203 has increased solubility and a longer half-life in mouse, rat, and human microsomes and isolated plasma than the ferroptosis inhibitor ferrostatin-1 . In an in silico membrane dynamics study, UAMC-3203 was incorporated into a phospholipid bilayer.

1.Devisscher, L., Van Coillie, S., Hofmans, S., et al.Discovery of novel, drug-like ferroptosis inhibitors with in vivo efficacyJ. Med. Chem.61(22)10126-10140(2018)