(R)-Baclofen hydrochloride

A GABAB receptor agonist

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库存: 现货

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数量
5mg

￥550.00

440.00

- +
10mg

￥775.00

620.00

- +
50mg

￥2475.00

1980.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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货号: ajce54214
CAS: 63701-55-3
别名: (R)-巴氯芬盐酸盐; Arbaclofen hydrochloride; STX 209 hydrochloride
分子式: C10H13Cl2NO2
分子量: 250.12
纯度: >98%
溶解度: DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 10 mg/ml,PBS (pH 7.2): 10 mg/ml
储存: Store at -20°C
库存: 现货

Background

(+)-Baclofen is a GABA_B receptor agonist.^1,2 In vivo, (+)-baclofen (1 and 3 mg/kg) increases latency to paw or tail withdrawal in the hot-plate test in mice.¹ (+)-Baclofen (3 mg/kg) also reduces the number of lever responses for alcohol in Sardinian alcohol-preferring rats.²

1.Thomas, D.A., Navarrete, I.M., Graham, B.A., et al.Antinociception produced by systemic R(+)-baclofen hydrochloride is attenuated by CGP 35348 administered to the spinal cord or ventromedial medulla of ratsBrain Res.718(1-2)129-137(1996) 2.Lorrai, I., Maccioni, P., Gessa, G.L., et al.R(+)-Baclofen, but not S(-)-baclofen, alters alcohol self-administration in alcohol-preferring ratsFront. Psychiatry768(2016)