(R)-Ofloxacin

A fluoroquinolone antibiotic

此产品仅用于科学研究，我们不为任何个人用途提供产品和服务

库存: 现货

可选规格

包装

价格

促销价

数量
5mg

￥8100.00

6480.00

- +

已选 0 种 0 瓶

金额: ￥0.00

首页收藏

货号: ajce54222
CAS: 100986-86-5
别名: (R)-氧氟沙星; Dextrofloxacin
分子式: C18H20FN3O4
分子量: 361.37
纯度: >98%
溶解度: DMF: 20 mg/ml,DMSO: 20 mg/ml,Ethanol: 1 mg/ml,PBS (pH 7.2): 10 mg/ml
储存: Store at -20°C
库存: 现货

Background

(R)-Ofloxacin is a fluoroquinolone antibiotic and the (R) isomer of the antibiotics ofloxacin and levofloxacin .¹ It is active against certain Gram-positive and Gram-negative bacteria, including E. coli, P. aeruginosa strains 32104 and 32122, S. aureus strains 209P and Smith, and S. epidermis strain 56556 (MICs = 0.78, 12.5, 6.25, 25, 12.5, and 25 ?g/ml, respectively) but not S. epidermis strain 56500, S. pyogenes, or S. faecalis (MICs = >100 ?g/ml for all).² (R)-Ofloxacin inhibits E. coli DNA gyrase with an IC₅₀ value of 75 ?g/ml, which is approximately 30- and 50-fold lower than inhibition by ofloxacin and levofloxacin, respectively.¹

1.Morrissey, I., Hoshino, K., Sato, K., et al.Mechanism of differential activities of ofloxacin enantiomersAntimicrob. Agents Chemother.40(8)1775-1784(1996) 2.Hayakawa, I., Atarashi, S., Yokohama, S., et al.Synthesis and antibacterial activities of optically active ofloxacinAntimicrob. Agents Chemother.29(1)163-164(1986)