(S)-Falcarinol

(S)-Falcarinol (Panaxynol)，人参中主要的聚乙炔之一，具有抗肿瘤活性。(S)-Falcarinol (Panaxynol) 是人参中最有效的抗血小板药物，其作用机制主要是抑制血栓素的形成。(S)-Falcarinol (Panaxynol) 是有效的 Nrf2 激活剂。

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Background

(S)-Falcarinol (Panaxynol), one of the major polyacetylenes isolated from Panax ginseng, has antitumor activity. (S)-Falcarinol (Panaxynol) is the most potent antiplatelet agent in ginseng and its mechanism of action is chiefly due to the inhibition of thromboxane formation. (S)-Falcarinol (Panaxynol) is a potent Nrf2 activator[1][2][3]. Nrf2[3]

[1]. Mayer SF, et al. Chemoenzymatic asymmetric total syntheses of antitumor agents (3R,9R,10R)- and (3S,9R,10R)-Panaxytriol and (R)- and (S)-Falcarinol from Panax ginseng using an enantioconvergent enzyme-triggered cascade reaction. J Org Chem. 2002 Dec 27;67(26):9115-21. [2]. Teng CM,et al. Antiplatelet actions of panaxynol and ginsenosides isolated from ginseng. Biochim Biophys Acta. 1989 Mar 24;990(3):315-20. [3]. Qu C, et al. Identifying panaxynol, a natural activator of nuclear factor erythroid-2 related factor 2 (Nrf2) from American ginseng as a suppressor of inflamed macrophage-induced cardiomyocyte hypertrophy. J Ethnopharmacol. 2015 Jun 20;168:326-36.