[10]-Shogaol

A phenol with diverse biological activities

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Background

10-Shogaol is a phenol that has been found in Z. officinale and has diverse biological activities.^1,2,3 It selectively inhibits COX-2 over COX-1 (IC₅₀s = 7.5 and >50 ?M, respectively).¹ 10-Shogaol (100 and 200 ?M) induces mortality in A. cantonensis larvae.² It scavenges DPPH radicals in a cell-free assay when used at a concentration of 100 ?M.³ 10-Shogal (2 ?M) increases proliferation of isolated human keratinocytes and fibroblasts and migration of isolated human keratinocytes in a wound healing assay.

1.van Breemen, R.B., Tao, Y., and Li, W.Cyclooxygenase-2 inhibitors in ginger (Zingiber officinale)Fitoterapia82(1)38-43(2011) 2.Lin, R.-J., Chen, C.-Y., Chung, L.-Y., et al.Larvicidal activities of ginger (Zingiber officinale) against Angiostrongylus cantonensisActa Trop.115(1-2)69-76(2010) 3.Chen, C.-Y., Cheng, K.-C., Chang, A.-Y., et al.10-Shogaol, an antioxidant from Zingiber officinale for skin cell proliferation and migration enhancerInt. J. Mol. Sci.13(2)1762-1777(2012)