1,3-Dicaffeoylquinic acid

An HIV-1 integrase inhibitor and free radical scavenger

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库存: 现货

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5mg

￥1025.00

820.00

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10mg

￥1600.00

1280.00

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25mg

￥3262.00

2610.00

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货号: ajce54316
CAS: 19870-46-3
别名: 1,3-二咖啡酰奎宁酸; 1,3-O-Dicaffeoylquinic acid; 1,5-Dicaffeoylquinic acid
分子式: C25H24O12
分子量: 516.45
纯度: >98%
溶解度: DMSO: 100 mg/mL (193.63 mM)
储存: Store at -20°C, protect from light
库存: 现货

Background

1,5-Dicaffeoylquinic acid (1,5-DCQA) has been found in A. montana and is an HIV-1 integrase inhibitor and free radical scavenger.^1,2 1,5-DCQA inhibits HIV-1 integrase 3' end processing, end joining, and disintegration with IC₅₀ values of 0.35, 0.56, and 0.84 μg/ml, respectively.² It also inhibits HIV-1 replication in MT-2 T lymphoblastoid cells with an ED₅₀value of 2 μg/ml. 1,5-DCQA (0.25-1 μM) reduces the level of free radicals released from human polymorphonuclear (PMN) cells stimulated by N-formyl-Met-Leu-Phe in a dose-dependent manner.¹ It also dose-dependently increases cell survival and glutathione (GSH) levels and decreases reactive oxygen species (ROS) production and lactate dehydrogenase (LDH) release in an oxygen-glucose deprivation/reperfusion assay in rat cerebral astrocytes when used at concentrations ranging from 5 to 100 ?M.³

1.Heilmann, J., Merfort, I., and Weiss, M.Radical scavenger activity of different 3',4'-dihydroxyflavonols and 1,5-dicaffeoylquinic acid studied by inhibition of chemiluminescencePlanta Med.61(5)435-438(1995) 2.Robinson, W.E., Jr., Cordeiro, M., Abdel-Malek, S., et al.Dicaffeoylquinic acid inhibitors of human immunodeficiency virus integrase: Inhibition of the core catalytic domain of human immunodeficiency virus integraseMol. Pharmacol.50(4)846-855(1996) 3.Cao, X., Xiao, H., Zhang, Y., et al.1, 5-Dicaffeoylquinic acid-mediated glutathione synthesis through activation of Nrf2 protects against OGD/reperfusion-induced oxidative stress in astrocytesBrain Res.1347142-148(2010)