10-Deacetyl-7-xylosyl paclitaxel

A microtubule disruptor

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10mg

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货号: ajce54330
CAS: 90332-63-1
别名: 7-木糖甙-10-脱乙酰基紫杉醇,10-Deacetyl-7-xylosyltaxol; 10-Deacetylpaclitaxel 7-Xyloside; 10-Deacetyltaxol 7-Xyloside
分子式: C50H57NO17
分子量: 943.98
纯度: >98%
溶解度: Water: < 0.1 mg/mL (insoluble)
储存: 4°C, protect from light
库存: 现货

Background

10-deactyl-7-xylosyl Paclitaxel is a disruptor of microtubules and derivative of paclitaxel that has been found in T. chinensis.^1,2 It induces the disassembly of pig brain and Physarum microtubules in cell-free assays (IC₅₀s = 0.3 and 0.5 ?M, respectively).¹ 10-deactyl-7-xylosyl Paclitaxel inhibits proliferation of (IC₅₀ = 5 ?M), as well as induces cell cycle arrest at the G₂/M phase and apoptosis in, PC3 prostate cancer cells.²

1.Lataste, H., Senilh, V., Wright, M., et al.Relationships between the structures of taxol and baccatine III derivatives and their in vitro action on the disassembly of mammalian brain and Physarum amoebal microtubulesProc. Natl. Acad. Sci. USA81(13)4090-4094(1984) 2.Jiang, S., Zu, Y., Fu, Y., et al.Activation of the mitochondria-driven pathway of apoptosis in human PC-3 prostate cancer cells by a novel hydrophilic paclitaxel derivative, 7-xylosyl-10-deacetylpaclitaxelInt. J. Oncol.33(1)103-111(2008)