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24R-Calcipotriol(PRI 2202)是钙泊三醇的杂质,钙泊三醇是1,25-Dihydroxyvitamin D3类似物。
货号:ajce54402
CAS:112827-99-3
分子式:C27H40O3
分子量:412.6
纯度:98%
存储:Store at -20°C
库存:现货
Background:
24R-Calcipotriol(PRI 2202) is an impurity of Calcipotriol; Calcipotriol (MC 903; Calcipotriene) is a ligand of VDR-like receptors.IC50 value:Target: Vitamin D3 analog that displays minimal effects on calcium homeostasis. Regulates cell differentiation and proliferation; Calcipotriol (MC 903; Calcipotriene) exhibits antiproliferative activity against human HL-60, HL60/MX2, MCF-7, T47D, SCC-25 and mouse WEHI-3 cancer cell lines.
参考文献:
[1]. Gocek, Elzbieta; Kielbinski, Marek; Baurska, Hanna et al. Different susceptibilities to 1,25-dihydroxyvitamin D3-induced differentiation of AML cells carrying various mutations. Leukemia Research (2010), 34(5), 649-657.
[2]. Gocek, Elzbieta; Kielbinski, Marek; Wylob, Paulina et al. Side-chain modified vitamin D analogs induce rapid accumulation of VDR in the cell nuclei proportionately to their differentiation-inducing potential. Steroids (2008), 73(14), 1359-1366.
[3]. Wietrzyk, Joanna; Nevozhay, Dmitry; Filip, Beata et al. The antitumor effect of lowered doses of cytostatics combined with new analogs of vitamin D in mice. Anticancer Research (2007), 27(5A), 3387-3398.
[4]. Wietrzyk, Joanna; Chodynski, Michal; Fitak, Hanna et al. Antitumor properties of diastereomeric and geometric analogs of vitamin D3. Anti-Cancer Drugs (2007), 18(4), 447-457.
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