7-Epi 10-desacetyl paclitaxel

A taxane diterpenoid with α-glucosidase inhibitory and anticancer activities

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5mg

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2310.00

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10mg

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货号: ajce54616
CAS: 78454-17-8
别名: 7-表-10-去乙酰基云南紫杉宁A,7-epi-10-deacetyltaxol; 10-Deacetyl-7-epipaclitaxel
分子式: C45H49NO13
分子量: 811.87
纯度: >98%
溶解度: Soluble in DMSO
储存: 4°C, protect from light
库存: 现货

Background

7-epi-10-Deacetyltaxol is a taxane diterpenoid and derivative of paclitaxel that has been found in Taxus and has α-glucosidase inhibitory and anticancer activities.^1,2 It inhibits α-glucosidase (IC₅₀ = 48.8 ?M) and is cytotoxic to HeLa cells (IC₅₀ = 0.085 nM).¹ 7-epi-10-Deacetyltaxol induces apoptosis and DNA fragmentation in HepG2 hepatocellular carcinoma cells in a concentration-dependent manner.²

1.Dang, P.H., Nguyen, H.X., Duong, T.T.T., et al.α-glucosidase inhibitory and cytotoxic taxane diterpenoids from the stem bark of Taxus wallichianaJ. Nat. Prod.80(4)1087-1095(2017) 2.Subban, K., Singh, S., Subramani, R., et al.Fungal 7-epi-10-deacetyltaxol produced by an endophytic Pestalotiopsis microspora induces apoptosis in human hepatocellular carcinoma cell line (HepG2)BMC Complement. Altern. Med.17(1)504(2017)