AC710 Mesylate

A PDGFR family kinase inhibitor

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库存: 现货

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价格

促销价

数量
2mg

￥1475.00

1180.00

- +
5mg

￥2225.00

1780.00

- +
10mg

￥3775.00

3020.00

- +
50mg

￥14112.00

11290.00

- +
100mg

￥22437.00

17950.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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Background

AC-710 is an inhibitor of PDGFR family kinases (IC₅₀s = 7.7, 10.5, 2, and 1.2 nM for PDGFRβ, CSF1R, FLT3, and c-Kit, respectively).¹ It is greater than 30-fold selective for PDGFR family kinases over a panel of 386 kinases, as well as over a panel of five cytochrome P450 (CYP) enzymes (IC₅₀s = >40 ?M). AC-710 (30 mg/kg) inhibits CSF1R-dependent M-NFS-60 murine leukemia cell proliferation and reduces tumor volume in an FLT3 mutant MV4-11 leukemia mouse xenograft model.

1.Liu, G., Campbell, B.T., Holladay, M.W., et al.Discovery of AC710, a globally selective inhibitor of platelet-derived growth factor receptor-family kinasesACS Med. Chem. Lett.3(12)997-1002(2012)

Protocol

Animal experiment:

Mice: The antitumor efficacy of AC710 is assessed in a subcutaneous flank-tumor xenograft model in athymic nude mice using the MV4-11cell line. AC710 is dosed at 0.3, 3, and 30 mg/kg for 2 weeks. Tumor growth and body weight is monitored[1].

参考文献:

[1]. Liu G, et al. Discovery of AC710, a Globally Selective Inhibitor of Platelet-Derived Growth Factor Receptor-Family Kinases. ACS Med Chem Lett. 2012 Sep 24;3(12):997-1002.