Allopurinol riboside

A ribonucleoside

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5mg

￥1300.00

1040.00

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10mg

￥0.00

0.00

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50mg

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0.00

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Background

Allopurinol riboside is a ribonucleoside and a ribose-containing derivative of the xanthine oxidase inhibitor allopurinol .¹ It inhibits the growth of Leishmania promastigotes and prevents amastigote maturation into the promastigote phase of the parasite life cycle in cell-free assays.² Allopurinol riboside (239, 511, and 929 mg/kg per day) prevents mortality in mouse models of T. cruzi infection but does not eradicate the infection.¹

1.Croft, S.L., and Neal, R.A.The effect of allopurinol ribonucleoside and formycin B on Trypanosoma cruzi infections in miceTrans. R. Soc. Trop. Med. Hyg.79(4)517-518(1985) 2.Nelson, D.J., LaFon, S.W., Tuttle, J.V., et al.Allopurinol ribonucleoside as an antileishmanial agent. Biological effects, metabolism, and enzymatic phosphorylation254(22)11544-11549(1979)