Alrestatin sodium

An aldose reductase inhibitor

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5mg

￥875.00

700.00

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10mg

￥1300.00

1040.00

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50mg

￥4850.00

3880.00

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Background

Alrestatin is an inhibitor of aldose reductase (IC₅₀ = 1.5 ?M for rat lens enzyme).¹ It is selective for rat lens aldose reductase over rat kidney aldehyde reductase (IC₅₀ = 58 ?M). Alrestatin reduces basal and tyramine-induced norepinephrine release in rat pancreatic preparations.² In vivo, alrestatin (0.75 mmol/kg) increases plasma insulin levels in fasted anesthetized rats. Alrestatin inhibits the lens and sciatic nerve accumulation of polyols in a rat model of streptozotocin-induced diabetes.³ It also inhibits gastric acid secretion and ulcer formation induced by pyloric ligation in rats (ED₅₀s = 90 and 330 mg/kg, respectively).

1.Sato, S., and Kador, P.F.Inhibition of aldehyde reductase by aldose reductase inhibitorsBiochem. Pharmacol.40(5)1033-1042(1990) 2.Kobric, M., and Lippmann, W.Effect of alrestatin sodium on glucose-stimulated insulin secretion in the fasted anaesthetized ratHorm. Metab. Res.10(6)495-500(1978) 3.Lippmann, W., Seethaler, K., Borella, L.E., et al.Alrestatin: Gastric acid antisecretory-antiulcer activity in the ratDigestion18(1-2)35-44(1978)