Anandamide

An endogenous cannabinoid

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库存: 现货

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1mg

￥250.00

200.00

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5mg

￥675.00

540.00

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10mg

￥1300.00

1040.00

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25mg

￥2537.00

2030.00

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货号: ajce54920
CAS: 94421-68-8
别名: 花生四烯酸乙醇胺
分子式: C22H37NO2
分子量: 347.53
纯度: >98%
溶解度: 30mg/mL in DMSO, or 10mg/mL in DMF
储存: Store at -20°C,stored under nitrogen
库存: 现货

Background

Arachidonoyl ethanolamide (AEA) is the ethanolamine amide of arachidonic acid, originally isolated from porcine brain.¹ AEA is an endogenous cannabinoid neurotransmitter that binds to both cannabinoid 1 (CB₁) and CB₂ receptors.² AEA has K_i values ranging from 61 to 543 nM for CB₁ receptors and from 279 to 1,940 nM for CB₂ receptors.³

1.Devane, W.A., Hanus, L., Breuer, A., et al.Isolation and structure of a brain constituent that binds to the cannabinoid receptorScience258(5090)1946-1949(1992) 2.Felder, C.C., Briley, E.M., Axelrod, J., et al.Anandamide, an endogenous cannabimimetic eicosanoid, binds to the cloned human cannabinoid receptor and stimulates receptor-mediated signal transductionProc. Natl. Acad. Sci. USA90(16)7656-7660(1993) 3.Pertwee, R.G.Pharmacology of cannabinoid receptor ligandsCurr. Med. Chem.6(8)635-664(1999)

Protocol

Animal experiment:

Mice[2]Eleven-week-old C57BL/6J male mice and global CB1R-/- mice are housed individually on a 12/12-h light/dark schedule at 22-23°C with ad libitum access to water and food. A group of mice is subject to a high-fat diet (30% lard). After 16 weeks of diet, animals with a weight gain less than +10 g compared with controls are excluded from the study. Diet-induced obesity (DIO) mice (39.1±1.1 vs. 27.3±0.9 g, DIO vs. control) are glucose intolerant and insulin resistant. On the day of each experiment, food is removed from the cages for 6 h (from 8:00 A.M. to 2:00 P.M.). Anandamide is administered intraperitoneally at 10 mg/kg. In control experiments, animals are injected with vehicle (4% DMSO/1% Tween 80)[2].

参考文献:

[1]. Malek N, et al. Anandamide, Acting via CB2 Receptors, Alleviates LPS-Induced Neuroinflammation in Rat Primary Microglial Cultures. Neural Plast. 2015;2015:130639.
[2]. Troy-Fioramonti S, et al. Acute activation of cannabinoid receptors by Anandamide reduces gastrointestinal motility and improves postprandial glycemia in mice. Diabetes. 2015 Mar;64(3):808-18.