Auristatin F

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100mg

￥0.00

0.00

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50mg

￥0.00

0.00

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1mg

￥3496.00

3146.00

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5mg

￥7492.00

6742.00

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10mg

￥11988.00

10789.00

- +

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Auristatin F是细胞毒性分子，微管蛋白修饰分子，强效抗肿瘤活性，MMAF的类似物以及在抗体药物偶连体开发中作为毒素分子。

货号：ajce55102
CAS：163768-50-1
分子式：C40H67N5O8
分子量：745.99
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Auristatin F is a cytotoxic tubulin modifier with potent and selective antitumor activity; MMAF analog and cytotoxin in Antibody-drug conjugates.

[1]. Temming K, et al. Improved efficacy of alphavbeta3-targeted albumin conjugates by conjugation of a novel auristatin derivative. Mol Pharm. 2007 Sep-Oct;4(5):686-94. [2]. Doronina SO, et al. Enhanced activity of monomethylauristatin F through monoclonal antibody delivery: effects of linker technology on efficacy and toxicity. Bioconjug Chem. 2006 Jan-Feb;17(1):114-24.