AZD1208 hydrochloride

A pan-Pim kinase inhibitor

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库存: 现货

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数量
5mg

￥650.00

520.00

- +
10mg

￥937.00

750.00

- +
50mg

￥3262.00

2610.00

- +
100mg

￥5175.00

4140.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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货号: ajce55136
CAS: 1621866-96-3
别名:
分子式: C21H22ClN3O2S
分子量: 415.94
纯度: >98%
溶解度: DMSO: 83.3 mg/mL (200.27 mM and warming)
储存: Store at -20°C
库存: 现货

Background

AZD 1208 is a potent, selective, and orally available inhibitor of all three forms of the proto-oncogene Pim kinase (IC₅₀s = 0.4, 5.0, and 1.9 nM for Pim-1, Pim-2, and Pim-3, respectively).¹ It causes cell cycle arrest and apoptosis in MOLM-16 megakaryoblastic leukemia cells and inhibits the growth of MOLM-16 xenograft tumors in mice.¹ It has efficacy against acute myeloid leukemia and glioblastoma cells when combined with mTOR and p110α inhibitors, respectively.^2,3

1.Keeton, E.K., McEachern, K., Dillman, K.S., et al.AZD1208, a potent and selective pan-Pim kinase inhibitor, demonstrates efficacy in preclinical models of acute myeloid leukemiaBlood123(6)905-913(2014) 2.Harada, M., Benito, J., Yamamaoto, S., et al.The novel combination of dual mTOR inhibitor AZD2014 and pan-PIM inhibitor AZD1208 inhibits growth in acute myeloid leukemia via HSF pathway suppressionOncotarget6(35)37930-37947(2015) 3.Iqbal, A., Eckerdt, F., Bell, J., et al.Targeting of glioblastoma cell lines and glioma stem cells by combined PIM kinase and PI3K-p110α inhibitionOncotarget7(22)33192-33201(2016)