Ceftriaxone

A third-generation cephalosporin antibiotic

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100mg

￥550.00

440.00

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500mg

￥987.00

790.00

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Background

Ceftriaxone is a third-generation, broad-spectrum cephalosporin antibiotic that disrupts the synthesis of the peptidoglycan layer of bacterial cell walls.^1,2,3 It has been shown to increase excitatory amino acid transporter-2 pump expression in the central nervous system and to reduce glutamatergic toxicity in both in vitro and in vivo models.⁴

1.Bush, K.β-Lactamase inhibitors from laboratory to clinicClin. Microbiol. Rev.1(1)109-123(1988) 2.Kalman, D., and Barriere, S.L.Review of the pharmacology, pharmacokinetics, and clinical use of cephalosporinsTex. Heart Inst. J.17(3)203-215(1990) 3.Neu, H.C.The in vitro activity, human pharmacology, and clinical effectiveness of new β-lactam antibioticsAnnu. Rev. Pharmacol. Toxicol.22599-642(1982) 4.Lee, S.G., Su, Z.Z., Emdad, L., et al.Mechanism of ceftriaxone induction of excitatory amino acid transporter-2 expression and glutamate uptake in primary human astrocytesJ. Biol. Chem.283(19)13116-13123(2008)