CP-640186 hydrochloride

An ACC inhibitor

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库存: 现货

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促销价

数量
2mg

￥650.00

520.00

- +
5mg

￥987.00

790.00

- +
10mg

￥1562.00

1250.00

- +
50mg

￥5175.00

4140.00

- +
100mg

￥8287.00

6630.00

- +
200mg

￥0.00

0.00

- +
500mg

￥0.00

0.00

- +

已选 0 种 0 瓶

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货号: ajce55722
CAS: 591778-70-0
别名: 盐酸CP-640186
分子式: C30H36ClN3O3
分子量: 522.08
纯度: >98%
溶解度: Water: 50 mg/mL (95.77 mM); DMSO: ≥ 48 mg/mL (91.94 mM)
储存: Store at -20°C
库存: 现货

Background

Acetyl-CoA carboxylase (ACC) is a key enzyme of fatty acid metabolism that enables the synthesis of malonyl-CoA, a precursor for fatty acids. CP 640,186 is an isozyme-nonselective ACC inhibitor with IC₅₀ values of 53 and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2, respectively.¹ It has been shown to lower malonyl-CoA levels and to inhibit hepatic fatty acid and triglyceride synthesis both in vitro and in vivo.¹ CP 640,186 can also stimulate muscle fatty acid oxidation (EC₅₀ = 1.3 ?M in rat epitrochlearis muscle strips) and lower whole body respiratory quotient in rats (ED₅₀ = ~30 mg/kg).¹

1.Harwood, H.J., Jr., Petras, S.F., Shelly, L.D., et al.Isozyme-nonselective N-substituted bipiperidylcarboxamide acetyl-CoA carboxylase inhibitors reduce tissue malonyl-CoA concentrations, inhibit fatty acid synthesis, and increase fatty acid oxidation in cultured cells and in experimental animalsJ. Biol. Chem.278(39)37099-37111(2016)