CZC-25146 hydrochloride

A potent LRRK2 inhibitor

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5mg

￥1225.00

980.00

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50mg

￥9387.00

7510.00

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Background

CZC-25146 is a potent inhibitor of leucine-rich repeat kinase 2 (LRRK2; IC₅₀ = 4.76 nM for the human recombinant kinase).¹ It also inhibits LRRK2^G2019S, a mutant linked to neurotoxicity and Parkinson’s disease, with an IC₅₀ value of 6.87 nM. CZC-25146 is selective for LRRK2 over a panel of kinases in HeLa cell lysates, Jurkat/Ramos mixed cell lysates, as well as whole mouse brain extracts (IC₅₀s = >2 μM). It reduces LRRK2^G2019S-induced cell injury in rat primary cortical neurons.

1.Ramsden, N.G., Perrin, J., Ren, Z., et al.Chemoproteomics-based design of potent LRRK2-selective lead compounds that attenuate Parkinson's disease-related toxicity in human neuronsACS Chem Biol.6(10)1021-1028(2011)