Danegaptide Hydrochloride

Danegaptide Hydrochloride (GAP-134 Hydrochloride) 是一种有效的、选择性的和口服活性的间隙连接调节剂，具有抗心律失常作用。

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库存: 现货

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数量
2mg

￥1000.00

800.00

- +
5mg

￥1625.00

1300.00

- +
10mg

￥2725.00

2180.00

- +
50mg

￥8100.00

6480.00

- +

已选 0 种 0 瓶

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货号: ajce55856
CAS: 943133-81-1
别名: (4R)-甘氨酰基-4-(苯甲酰基氨基)-L-脯氨酸盐酸盐,GAP-134 Hydrochloride; ZP 1609 Hydrochloride
分子式: C14H18ClN3O4
分子量: 327.76
纯度: >98%
溶解度: Water: ≥ 75 mg/mL (228.83 mM); DMSO: ≥ 55 mg/mL (167.81 mM)
储存: Store at -20°C
库存: 现货

Background

Danegaptide Hydrochloride (GAP-134 Hydrochloride) is a selective modifier of the gap junction protein. Gap junction.

[1]. De Vuyst E, Boengler K, Antoons G, et al. Pharmacological modulation of connexin-formed channels in cardiac pathophysiology. Br J Pharmacol. 2011 Jun;163(3):469-83. [2]. Laurent G, Leong-Poi H, Mangat I, et al. Effects of chronic gap junction conduction-enhancing antiarrhythmic peptide GAP-134 administration on experimental atrial fibrillation in dogs. Circ Arrhythm Electrophysiol. 2009 Apr;2(2):171-8. [3]. Hennan JK, Swillo RE, Morgan GA, et al. GAP-134 ([2S,4R]-1-[2-aminoacetyl]4-benzamidopyrrolidine-2-carboxylic acid) prevents spontaneous ventricular arrhythmias and reduces infarct size during myocardial ischemia/reperfusion injury in open-chest dogs. J Cardiovasc Pharmacol Ther. 2009 Sep;14(3):207-14. [4]. Rossman EI, Liu K, Morgan GA, et al. The gap junction modifier, GAP-134 [(2S,4R)-1-(2-aminoacetyl)-4-benzamido-pyrrolidine-2-carboxylic acid], improves conduction and reduces atrial fibrillation/flutter in the canine sterile pericarditis model. J Pharmacol Exp Ther. 2009 Jun;329(3):1127-33. [5]. Eugene L. Piatnitski Cheklera, John A. Buterab, Li Dib, Discovery of a class of potent gap-junction modifiers as novel antiarrhythmic agents. Bioorganic & Medicinal Chemistry Letters. 2009,19(16): 4551-4554