Delavirdine

A non-nucleoside reverse transcriptase inhibitor

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库存: 现货

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包装

价格

促销价

数量
10mg

￥562.00

450.00

- +
50mg

￥1050.00

840.00

- +
100mg

￥1900.00

1520.00

- +
200mg

￥3137.00

2510.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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Background

Delavirdine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that selectively inhibits HIV-1 reverse transcriptase over DNA polymerase α and δ in vitro (IC₅₀s = 0.26, 440, and >550 μM, respectively).¹ It inhibits growth of clinical isolates of HIV-1 (ED₅₀s = <0.005-0.69 μM). Delavirdine blocks replication of 25 primary HIV-1 isolates, including strains resistant to 3'-azido-2',3'-deoxythymidine (AZT) or 2',3'-dideoxyinosine, with a mean ED₅₀ value of 0.066 μM. Delavirdine also inhibits growth of L. infantum promastigotes (IC₅₀ = 26.1 μM).² Formulations containing delavirdine have been used in the treatment of HIV.

1.Dueweke, T.J., Poppe, S.M., Romero, D.L., et al.U-90152, a potent inhibitor of human immunodeficiency virus type 1 replicationAntimicrob. Agents Chemother.37(5)1127-1131(1993) 2.Costa, S., Machado, M., Cavadas, C., et al.Antileishmanial activity of antiretroviral drugs combined with miltefosineParasitol Res.115(10)3881-3887(2016)