Diazepinomicin

Diazepinomicin (TLN-4601) 是Micromonospora sp 的次生代谢产物，可抑制EGF 诱导的 Ras-ERK MAPK 信号通路，可诱导凋亡。是一种可用于 K-Ras 突变型的抗肿瘤药物。

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货号: ajce55960
CAS: 733035-26-2
别名: ECO-4601; TLN-4601; BU 4664L
分子式: C28H34N2O4
分子量: 462.58
纯度: >98%
溶解度: Soluble in DMSO
储存: Store at -20°C, protect from light, stored under nitrogen
库存: 现货

Background

Diazepinomicin (TLN-4601) is a secondary metabolite produced by Micromonospora sp. Diazepinomicin (TLN-4601) inhibits the EGF-induced Ras-ERK MAPK signaling pathway and induces apoptosis. An anti-tumor agent for K-Ras mutant models[1]. Diazepinomicin (TLN-4601) inhibits the EGF-induced Ras-ERK MAPK signaling pathway post Ras prenylation and prior to MEK activation[1].

[1]. Campbell PM, et al. TLN-4601 suppresses growth and induces apoptosis of pancreatic carcinoma cells through inhibition of Ras-ERK MAPK signaling. J Mol Signal. 2010 Nov 2;5:18.