Emapunil

A TSPO agonist

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库存: 现货

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5mg

￥1212.00

970.00

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10mg

￥1900.00

1520.00

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50mg

￥7125.00

5700.00

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100mg

￥11875.00

9500.00

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200mg

￥0.00

0.00

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500mg

￥0.00

0.00

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已选 0 种 0 瓶

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Background

AC-5216 is a high affinity agonist of the 18 kDa translocator protein (TSPO, previously called the peripheral benzodiazepine receptor) that exhibits a K_i value of 0.297 nM in rat whole brain and IC₅₀ values of 2.73 and 3.04 nM, respectively, against human and rat glial TSPO.¹ AC-5216 produces anxiolytic and antidepressant effects in various animal models, without inducing benzodiazepine-like adverse effects.^1,2

1.Kita, A., Kohayakawa, H., Kinoshita, T., et al.Antianxiety and antidepressant-like effects of AC-5216, a novel mitochondrial benzodiazepine receptor ligandBr. J. Pharmacol.1421059-1072(2004) 2.Qiu, Z.K., Zhang, L.M., Zhao, N., et al.Repeated administration of AC-5216, a ligand for the 18 kDa translocator protein, improves behavioral deficits in a mouse model of post-traumatic stress disorderProg. Neuropsychopharmacol. Biol. Psychiatry4540-46(2013)