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  • EN6
    EN6的可视化放大

    EN6

    An activator of autophagy

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    EN6的二维码
    • 库存: 现货
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    • 包装
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      促销价
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    • 1mg
      ¥400.00
      320.00
      - +
    • 5mg
      ¥1000.00
      800.00
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    • 10mg
      ¥1700.00
      1360.00
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    • 50mg
      ¥4575.00
      3660.00
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    • 100mg
      ¥5075.00
      4060.00
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    金额: ¥0.00
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    • 货号: ajce56206
    • CAS: 1808714-73-9
    • 别名:
    • 分子式: C19H14F2N4O2
    • 分子量: 368.34
    • 纯度: >98%
    • 溶解度: DMSO: 5 mg/mL (13.57 mM)
    • 储存: Store at -20°C
    • 库存: 现货

    Background

    EN6 is an activator of autophagy.1 It inhibits mammalian target of rapamycin complex 1 (mTORC1) signaling by binding covalently to cysteine 277 of the ATP6V1A catalytic subunit of the lysosomal vacuolar ATPase (v-ATPase) and impairing v-ATPase coupling with Rag GTPases. It is selective for inhibition of mTORC1 over mTORC2 signaling. EN6 increases lysosome acidification and increases cellular clearance of TDP-43 protein aggregates, which are a pathological feature of several neurodegenerative diseases, in a v-ATPase-dependent manner in U2OS osteosarcoma cells. It also inhibits mTORC1 signaling and enhances autophagy in mouse skeletal muscle and heart when administered at a dose of 50 mg/kg.


    1.Chung, C.Y.-S., Shin, H.R., Berdan, C.A., et al.Covalent targeting of the vacuolar H+-ATPase activates autophagy via mTORC1 inhibitionNat. Chem. Biol.15776-785(2019)

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