ESI-05

An Epac2 inhibitor

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库存: 现货

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数量
5mg

￥650.00

520.00

- +
10mg

￥1150.00

920.00

- +
50mg

￥3487.00

2790.00

- +
100mg

￥5937.00

4750.00

- +
200mg

￥0.00

0.00

- +
500mg

￥0.00

0.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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Background

ESI-05 is an inhibitor of exchange protein activated by cAMP 2 (Epac2) that inhibits cAMP-induced Epac2 guanine nucleotide exchange factor (GEF) activity with an IC₅₀ value of 0.43 ?M in a cell-free assay.¹ It is selective for Epac2 over Epac1 and PKA at 25 ?M. ESI-05 (1, 5, 10, and 25 ?M) reduces activation of the GTPase RAP1 induced by the Epac-selective cAMP analog 007-AM in HEK293 cells expressing Epac2 but has no effect in HEK293 cells expressing Epac1.

1.Tsalkova, T., Mei, F.C., Li, S., et al.Isoform-specific antagonists of exchange proteins directly activated by cAMPProc. Natl. Acad. Sci. USA109(45)18613-18618(2012)