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Eupatorin

A flavonoid with diverse biological activities

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Eupatorin的二维码
  • 库存: 现货
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  • 包装
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    促销价
    数量
  • 5mg
    ¥1212.00
    970.00
    - +
  • 10mg
    ¥2062.00
    1650.00
    - +
  • 20mg
    ¥3525.00
    2820.00
    - +
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  • 货号: ajce56276
  • CAS: 855-96-9
  • 别名: 半齿泽兰素
  • 分子式: C18H16O7
  • 分子量: 344.32
  • 纯度: >98%
  • 溶解度: DMF: 10 mg/ml,DMSO: 10 mg/ml,DMSO:PBS (pH 7.2) (1:9): 0.1 mg/ml
  • 储存: Store at -20°C
  • 库存: 现货

Background

Eupatorin is a flavonoid that has been found in L. camara and has diverse biological activities.1,2,3,4 It inhibits the growth of HeLa, MK-1, and B16/F10 tumor cells (GI50s = 15, 58, and 44 ?M, respectively).1 Eupatorin is active against T. cruzi epimastigotes and trypomastigotes (IC50s = 0.2 and 61.8 ?g/ml, respectively) without inducing cytotoxicity in Vero cells (IC50 = >500 ?g/ml).2 It induces vasorelaxation in isolated rat thoracic aortic rings precontracted with phenylephrine (pD2 = 6.66).3 Eupatorin (10 and 100 ?M) reduces nuclear translocation of NF-κB and STAT1α in J774 murine macrophages and reduces paw edema in a mouse model of carrageenan-induced paw inflammation when administered at a dose of 50 mg/kg.4


1.Nagao, T., Abe, F., Kinjo, J., et al.Antiproliferative constituents in plants 10. Flavones from the leaves of Lantana montevidensis Briq. and consideration of structure-activity relationshipBiol. Pharm. Bull.25(7)875-879(2002) 2.Beer, M.F., Frank, F.M., Germán Elso, O., et al.Trypanocidal and leishmanicidal activities of flavonoids isolated from Stevia satureiifolia var. satureiifoliaPharm. Biol.54(10)2188-2195(2016) 3.Yam, M.F., Tan, C.S., Ahmad, M., et al.Mechanism of vasorelaxation induced by eupatorin in the rats aortic ringEur. J. Pharmacol.78927-36(2016) 4.Laavola, M., Nieminen, R., Yam, M.F., et al.Flavonoids eupatorin and sinensetin present in Orthosiphon stamineus leaves inhibit inflammatory gene expression and STAT1 activationPlanta Med.78(8)779-786(2012)

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