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Fiacitabine

Fiacitabine(NSC 382097; FIAC; FOAC)是选择性HSV DNA复制抑制剂,对HSV1和HSV2的IC50分别为2.5 nM和12.6 nM。

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Fiacitabine的二维码
  • 库存: 现货
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  • 5mg
    ¥3775.00
    3020.00
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  • 10mg
    ¥5400.00
    4320.00
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  • 50mg
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    0.00
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  • 货号: ajce56320
  • CAS: 69123-90-6
  • 别名: 非西他滨; NSC 382097; FIAC; FOAC
  • 分子式: C9H11FIN3O4
  • 分子量: 371.1
  • 纯度: >98%
  • 溶解度: DMSO: ≥ 37 mg/mL (99.70 mM)
  • 储存: Store at -20°C
  • 库存: 现货

Background

Fiacitabine(NSC 382097; FIAC; FOAC) is a selective inhibitior of DNA replication of herpes simplex virus(HSV) with IC50 values of 2.5 nM and 12.6 nM for HSV1 and HSV2, respectively. IC50 value: 2.5/12.6 nM (HSV1/2) [2]Target: HSVFIAC suppressed by 90% the replication of various strains of herpes simplex virus types 1 and 2 at concentrations of 0.0025 to 0.0126 microM. Cytotoxicity was minimal, as determined by trypan blue dye exclusion with norman Vero, WI-38, and NC-37 cell proliferation; the 50% inhibitory dose was 4 to 10 microM in a 4-day assay. FIAC was active at much lower concentrations than arabinosylcytosine, iododeoxyuridine, and arabinosyladenine. It was slightly more active against herpes simplex virus type 1 than acycloquanosine and slightly more toxic to normal cells. FIAC was about 8,000 times more active against the replication of wild-type herpes simplex virus type 1 than against a mutant strain lacking the expression of virus-specified thymidine kinase [2].



[1]. Allaudeen HS, et al. Selective inhibition of DNA replication in herpes simplex virus infected cells by 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-iodocytosine. J Biol Chem. 1982 Oct 25;257(20):11879-82. [2]. Lopez C, et al. 2'-fluoro-5-iodo-aracytosine, a potent and selective anti-herpesvirus agent. Antimicrob Agents Chemother. 1980 May;17(5):803-6.

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