Foxy-5

A Wnt5a peptide mimetic

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库存: 现货

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1mg

￥1300.00

1040.00

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5mg

￥3262.00

2610.00

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货号: ajce56388
CAS: 881188-51-8
别名: N-甲酰-L-甲酰-L-Α-天冬氨酸-甘氨酸-L-胱氨酸-L-Α-谷氨酰胺-L-亮氨酸
分子式: C26H42N6O12S2
分子量: 694.77
纯度: >98%
溶解度: Soluble in DMSO
储存: Store at -20°C
库存: 现货

Background

Foxy-5 is a Wnt5a peptide mimetic with anticancer activity.^1,2 It increases adhesion and reduces cell motility of MDA-MB-468 breast cancer cells when used at concentrations ranging from 1 to 1,000 ?M.¹ Foxy-5 (2 mg/kg) reduces the number of lymph node metastases without affecting primary tumor growth in a DU145-Luc mouse xenograft model.²

1.S?fholm, A., Leandersson, K., Dejmek, J., et al.A formylated hexapeptide ligand mimics the ability of Wnt-5a to impair migration of human breast epithelial cellsJ. Biol. Chem.281(5)2740-2749(2006) 2.Canesin, G., Evans-Axelsson, S., Hellsten, R., et al.Treatment with the WNT5A-mimicking peptide Foxy-5 effectively reduces the metastatic spread of WNT5A-low prostate cancer cells in an orthotopic mouse modelPLoS One12(9)e0184418(2017)