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  • Gamma-glutamylcysteine (TFA)
    Gamma-glutamylcysteine (TFA)的可视化放大

    Gamma-glutamylcysteine (TFA)

    Gamma-glutamylcysteine (TFA) ((γ-glutamylcysteine (TFA))是谷胱甘肽 (GSH) 合成的中间体,一种作为抗氧化酶谷胱甘肽过氧化物酶 (GPx) 的必需辅助因子的二肽。 Gamma-glutamylcysteine (TFA) 上调抗炎细胞因子 IL-10 的水平,降低促炎细胞因子 (TNF-α,IL-6 和 IL-1β) 的水平,并减弱在寡聚 Aβ40 处理的星形胶质细胞中金属蛋白酶活性的变化。

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    Gamma-glutamylcysteine (TFA)的二维码
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    • 货号: ajce56454
    • CAS: 283159-88-6
    • 别名: γ-Glutamylcysteine TFA
    • 分子式: C10H15F3N2O7S
    • 分子量: 364.3
    • 纯度: >98%
    • 溶解度: Soluble in DMSO
    • 储存: Store at -20°C
    • 库存: 现货

    Background

    Gamma-glutamylcysteine (TFA) ((γ-glutamylcysteine (TFA)), an intermediate in glutathione (GSH) synthesis, is a dipeptide served as an essential cofactor for the antioxidant enzyme glutathione peroxidase (GPx). Gamma-glutamylcysteine (TFA) also upregulates the level of the anti-inflammatory cytokine IL-10 and reduces the levels of the pro-inflammatory cytokines (TNF-α, IL-6, and IL-1β) and attenuates the changes in metalloproteinase activity in oligomeric Aβ40-treated astrocytes[1]. IL-10 IL-6 IL-1β TNF-α



    [1]. Braidy N, et al. The Precursor to Glutathione (GSH), γ-Glutamylcysteine (GGC), Can Ameliorate Oxidative Damage and Neuroinflammation Induced by Aβ40 Oligomers in Human Astrocytes. Front Aging Neurosci. 2019 Aug 8;11:177.

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