Gomisin J

A lignan with diverse biological activities

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库存: 现货

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1mg

￥1087.00

870.00

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5mg

￥3162.00

2530.00

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货号: ajce56598
CAS: 66280-25-9
别名: 戈米辛J
分子式: C22H28O6
分子量: 388.45
纯度: >98%
溶解度: DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,Ethanol:PBS (pH 7.2) (1:5): 0.16 mg/ml
储存: 4°C, protect from light
库存: 现货

Background

Gomisin J is a lignan that has been found in Schisandra chinensis and has diverse biological activities.^1,2 It inhibits HIV-1 IIIB replication in H9 T cells (EC₅₀ = 1.5 ?g/ml).¹ Gomisin J (20 ?M) decreases LPS-induced increases in nitric oxide (NO) production and p38, ERK, and JNK phosphorylation in RAW 264.7 cells.² It induces relaxation of isolated, precontracted endothelium-intact rat aortic rings when used at concentrations of 3, 10, and 30 ?g/ml.³ Gomisin J is cytotoxic to 13 cancer cell lines, including breast, colon, and cervical cancer cells, when used at a concentration of 30 ?g/ml.⁴

1.Chen, D.-F., Zhang, S.-X., Xie, J.-X., et al.Anti-AIDS agents—XXVI. Structure-activity correlations of gomisin-G-related anti-HIV lignans from Kadsura interior and of related synthetic analoguesBioorg. Med. Chem.5(8)1715-1723(1997) 2.Oh, S.-Y., Kim, Y.H., Bae, D.S., et al.Anti-inflammatory effects of gomisin J, and Schisandrin C isolated from the fruit of Schisandra chinensisBiosci. Biotechnol. Biochem.74(2)285-291(2010) 3.Park, J.Y., Hoi, Y.W., Yun, J.W., et al.Gomisin J from Schisandra chinensis induces vascular relaxation via activation of endothelial nitric oxide synthaseVascul. Pharmacol.57(2-4)124-130(2012) 4.Jung, S., Moon, H.-I., Kim, S., et al.Anticancer activity of gomisin J from Schisandra chinensis fruitOncol. Rep.41(1)711-717(2019)