GSK-626616

An inhibitor of DYRK3

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Background

GSK626616 is an inhibitor of dual-specificity tyrosine phosphorylation-regulated kinase 3 (DYRK3; IC₅₀ = 0.7 nM).¹ It enhances erythropoietin-induced erythropoiesis in isolated human bone marrow. GSK626616 increases hemoglobin levels in a mouse model of carboplatin- and radiation-induced anemia.

1.Erickson-Miller, C.L., Creasy, C., Chadderton, A., et al.GSK626616: A DYRK3 inhibitor as a potential new therapy for the treatment of anemia.Blood110(11)510(2007)