GW-406381

A NSAID and COX-2 inhibitor

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库存: 现货

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1mg

￥1350.00

1080.00

- +
5mg

￥0.00

0.00

- +
10mg

￥0.00

0.00

- +

已选 0 种 0 瓶

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Background

GW 406381 is a non-steroidal anti-inflammatory drug (NSAID) and COX-2 inhibitor (IC₅₀ = 3 nM).¹ It is selective for COX-2 over COX-1 (IC₅₀ = >84.2 ?M). GW 406381 (5 mg/kg) reverses chronic construction injury-induced decreases in paw withdrawal thresholds in a rat model of neuropathic pain.²

1.Beswick, P., Bingham, S., Bountra, C., et al.Identification of 2,3-diaryl-pyrazolo[1,5-b]pyridazines as potent and selective cyclooxygenase-2 inhibitorsBioorg. Med. Chem. Lett.14(21)5445-5448(2004) 2.Zhao, F.-Y., Spanswick, D., Martindale, J.C., et al.GW406381, a novel COX-2 inhibitor, attenuates spontaneous ectopic discharge in sural nerves of rats following chronic constriction injuryPain128(1-2)78-87(2007)