Indibulin

An inhibitor of microtubule assembly

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5mg

￥1212.00

970.00

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10mg

￥1737.00

1390.00

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50mg

￥6262.00

5010.00

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100mg

￥11012.00

8810.00

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200mg

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0.00

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500mg

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货号: ajce56858
CAS: 204205-90-3
别名: 2-(1-(4-氯苄基)-1H-吲哚-3-基)-2-氧代-N-(吡啶-4-基)乙酰胺,ZIO 301; D 24851
分子式: C22H16ClN3O2
分子量: 389.83
纯度: >98%
溶解度: DMSO: 50 mg/mL (128.26 mM)
储存: Store at -20°C
库存: 现货

Background

Indibulin is an inhibitor of microtubule assembly.¹ It destabilizes microtubules and is selective for immature neuronal and nonneuronal microtubules over mature neuronal microtubules.² Indibulin is cytotoxic to a variety of cancer cells, including human SKOV3 ovarian, U87 glioblastoma, and AsPC-1 pancreatic cancer cells (IC₅₀s = 36, 77, and 285 nM, respectively).¹ It also induces complete tumor regression in a rat Yoshida AH13 sarcoma model when administered at a dose of 10 mg/kg without inducing systemic or neurotoxicity.

1.Bacher, G., Nickel, B., Emig, P., et al.D-24851, a novel synthetic microtubule inhibitor, exerts curative antitumoral activity in vivo, shows efficacy toward multidrug-resistant tumor cells, and lacks neurotoxicityCancer Res.61(1)392-399(2001) 2.Wienecke, A., and Bacher, G.Indibulin, a novel microtubule inhibitor, discriminates between mature neuronal and nonneuronal tubulinCancer Res.69(1)171-177(2009)