Isomerazin

A coumarin with antioxidant and anti-inflammatory activities

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5mg

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Background

Isomeranzin is a coumarin that has been found in C. grandis and has antioxidant and anti-inflammatory activities.^1,2 It inhibits superoxide anion generation in, and elastase release from, isolated human neutrophils stimulated with cytochalasin B and fMLP (IC₅₀s = 3.89 and 4.33 ?M, respectively).¹ Isomeranzin (30 ?M) inhibits LPS-induced nitric oxide (NO) release in RAW 264.7 macrophages.² It improves survival in a mouse model of LPS-induced septic shock and decreases disease severity in a mouse model of colitis induced by dextran sulfate when administered at a dose of 30 mg/kg.

1.Kuo, P.-C., Liao, Y.-R., Hung, H.-Y., et al.Anti-inflammatory and neuroprotective constituents from the peels of Citrus grandisMolecules22(6)967(2017) 2.Xu, G., Feng, L., Song, P., et al.Isomeranzin suppresses inflammation by inhibiting M1 macrophage polarization through the NF-κB and ERK pathwayInt. Immunopharmacol.38175-185(2016)