JHU-083

JHU-083 (Ethyl 2-(2-Amino-4-methylpentanamido)-DON) is a novel prodrug of DON.JHU-083 selectively blocks glutaminase activity in brain CD11b+ cells and prevents depression-associated behaviors induced by chronic social defeat stress.Solutions are best fre

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1mg

￥3487.00

2790.00

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5mg

￥7012.00

5610.00

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10mg

￥11875.00

9500.00

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货号: ajce56978
CAS: 1998725-11-3
别名:
分子式: C14H24N4O4
分子量: 312.36
纯度: >98%
溶解度: DMSO: 100 mg/mL (320.14 mM)
储存: Store at -20°C, protect from light, stored under nitrogen
库存: 现货

Background

JHU-083 selectively inhibits T-cell proliferation and decreases T-cell activation, with no e?ect on DCs.[2]

In vivo, orally administered JHU-083 significantly decreases the experimental autoimmune encephalomyelitis(EAE) severity in both prevention and treatment paradigms and reverses EAE-induced cognitive impairment.[2]

[1] Zhu X,et al.Neuropsychopharmacology.2019;44(4):683-694 [2] Hollinger KR,et al.Neurol Neuroimmunol Neuroinflamm.2019 29;6(6)