L-Cysteine hydrochloride

A conditionally essential amino acid

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1g

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Background

L-Cysteine is a conditionally essential amino acid.^1,2 It is produced from L-methionine through the transsulfuration pathway.¹ L-Cysteine can also be derived from dietary sources and protein turnover. It is a precursor in the biosynthesis of the intracellular antioxidant glutathione . L-Cysteine supplementation increases GSH levels as well as decreases oxidative stress and pro-inflammatory cytokine levels in various rat and porcine disease models, including type 2 diabetes, aging, and inflammatory bowel disease (IBD). It is also an excitotoxin, inducing neuronal damage by overactivation of NMDA receptors.²

1.Yin, J., Ren, W., Yang, G., et al.L-Cysteine metabolism and its nutritional implicationsMol. Nutr. Food Res.60(1)134-146(2016) 2.Janáky, R., Varga, V., Hermann, A., et al.Mechanisms of L-cysteine neurotoxicityNeurochem. Res.25(9-10)1397-1405(2000)