LY-2940094

LY-2940094 是一种口服有效的选择性 nociceptin 受体 (NOP 受体) 拮抗剂，对 NOP 受体具有高亲和力(Ki 为 0.105 nM) 和拮抗活力 (Kb=0.166 nM)。LY-2940094 可降低动物模型的自身给药酒精依赖。

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5mg

￥2175.00

1740.00

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10mg

￥3775.00

3020.00

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25mg

￥7550.00

6040.00

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50mg

￥9700.00

7760.00

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100mg

￥15100.00

12080.00

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200mg

￥0.00

0.00

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500mg

￥0.00

0.00

- +

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Background

LY-2940094 is a potent, selective and orally available nociceptin receptor (NOP receptor) antagonist with high affinity (Ki=0.105 nM) and antagonist potency (Kb=0.166 nM). LY-2940094 reduces ethanol self-administration in animal models[1]. Ki: 0.105 nM (NOP receptor)[1]Kb: 0.166 nM (NOP receptor)[1]

LY-2940094 (LY2940094; 3, 10, or 30 mg/kg; 2-3 mL/kg; orally daily; for 4 days) dose-dependently reduces homecage ethanol self-administration in Indiana Alcohol-Preferring (P) and Marchigian Sardinian Alcohol-Preferring (msP) rats, without affecting food/water intake or locomotor activity[1]. Animal Model: Female Alcohol-Preferring (P) rats (250-320 g); Male Marchigian Sardinian Alcohol-Preferring (msP) rats (400-450 g)[1]

[1]. Rorick-Kehn LM, et al. A Novel, Orally Bioavailable Nociceptin Receptor Antagonist, LY2940094, Reduces Ethanol Self-Administration and Ethanol Seeking in Animal Models. Alcohol Clin Exp Res. 2016 May;40(5):945-54.