LY334370

A 5-HT1F receptor agonist

此产品仅用于科学研究，我们不为任何个人用途提供产品和服务

库存: 现货

可选规格

包装

价格

促销价

数量
5mg

￥1087.00

870.00

- +
10mg

￥1675.00

1340.00

- +
25mg

￥3600.00

2880.00

- +
50mg

￥6362.00

5090.00

- +
100mg

￥11337.00

9070.00

- +
200mg

￥0.00

0.00

- +
500mg

￥0.00

0.00

- +

已选 0 种 0 瓶

金额: ￥0.00

首页收藏

货号: ajce57264
CAS: 182563-08-2
别名: 4-氟-N-(3-(1-甲基哌啶-4-基)-1H-吲哚-5-基)苯甲酰胺盐酸盐
分子式: C21H22FN3O
分子量: 351.42
纯度: >98%
溶解度: DMSO: ≥ 55.5 mg/mL (157.93 mM)
储存: Store at -20°C
库存: 现货

Background

LY334370 is an agonist of the serotonin (5-HT) receptor subtype 5-HT_1F (K_d = 0.446 nM).¹ It is selective for 5-HT_1F over other G protein-coupled 5-HT receptor subtypes with K_i values ranging from 16.4 to greater than 3,000 nM in radioligand binding assays. LY334370 inhibits forskolin-induced cAMP accumulation in mouse L-M(TK-) cell membranes expressing the recombinant human 5-HT_1F receptor (EC₅₀ = 1.51 nM).² It decreases electrically stimulated extravasation of plasma proteins in the dura mater in a guinea pig trigeminal nerve model of migraine headache.

1.Wainscott, D.B., Krushinski, J.H., Jr., Audia, J.E., et al.[3H]LY334370, a novel radioligand for the 5-HT1F receptor. I. In vitro characterization of binding propertiesNaunyn Schmiedebergs Arch. Pharmacol.371(3)169-177(2005) 2.Johnson, K.W., Schaus, J.M., Durkin, M.M., et al.5-HT1F receptor agonists inhibit neurogenic dural inflammation in guinea pigsNeuroreport8(9-10)2237-2240(1997)