Mal-PEG2-VCP-Eribulin

Mal-PEG2-VCP-Eribulin 由 ADC linker (Mal-PEG2-VCP) 和 Eribulin 偶联而成。Eribulin 是一种独特的微管 (microtubule) 抑制剂，具有抗肿瘤活性。Mal-PEG2-VCP-Eribulin 可用于偶联抗体。

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库存: 现货

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1mg

￥10800.00

8640.00

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5mg

￥19237.00

15390.00

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货号: ajce57308
CAS: 2130869-18-8
别名:
分子式: C70H99N7O21
分子量: 1374.57
纯度: >98%
溶解度: Soluble in DMSO
储存: 4°C, protect from light, stored under nitrogen
库存: 现货

Background

Mal-PEG2-VCP-Eribulin consists the ADCs linker (Mal-PEG2-VCP) and Eribulin[1]. Eribulin is a mechanistically unique microtubule inhibitor for cancer[2]. Mal-PEG2-VCP-Eribulin is an Eribulin-based drug for antibody conjugates[1].

[1]. Earl F Albone, et al. Eribulin-based antibody-drug conjugates and methods of use. US20170252458A1. [2]. Towle MJ, et al. Eribulin induces irreversible mitotic blockade: implications of cell-based pharmacodynamics for in vivo efficacy under intermittent dosing conditions. Cancer Res. 2011 Jan 15;71(2):496-505.