MC-Val-Cit-PAB-duocarmycin

MC-Val-Cit-PAB-duocarmycin 是一种用于 ADC 的药物-接头偶联物，通过使用 Duocarmycin（一种 DNA 小沟结合烷化剂），通过 ADC 接头 MC-Val-Cit-PAB 连接，具有有效的抗肿瘤活性。

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货号: ajce57384
CAS: 2055896-98-3
别名:
分子式: C54H65ClN9O9
分子量: 1019.6
纯度: >98%
溶解度: Soluble in DMSO
储存: Store at -20°C, protect from light, stored under nitrogen,unstable in solution, ready to use.
库存: 现货

Background

MC-Val-Cit-PAB-duocarmycin has a bioreversible linkage based on a quaternary ammonium for targeted delivery and it can improve pharmacokinetics and the therapeutic index. MC-Val-Cit-PAB-duocarmycin is used for the antibody-drug conjugates (ADC) that are effective and stable in vitro and in vivo to treat various diseases or disorders[1].

[1]. Staben LR, et al. Targeted drug delivery through the traceless release of tertiary and heteroaryl amines from antibody-drug conjugates. Nat Chem. 2016 Dec;8(12):1112-1119.