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MD2-TLR4-IN-1

MD2-TLR4-IN-1 (Compound 22m) is a potent inhibitor of myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4). MD2-TLR4-IN-1 (compound 22m) inhibits lipopolysaccharide (LPS)-induced expression of tumor necrosis factor alpha (TNF-α) and interleuk

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  • 库存: 现货
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  • 5mg
    ¥3775.00
    3020.00
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  • 10mg
    ¥5937.00
    4750.00
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  • 25mg
    ¥10687.00
    8550.00
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  • 货号: ajce57398
  • CAS: 2249801-12-3
  • 别名:
  • 分子式: C22H14Cl2N4O
  • 分子量: 421.28
  • 纯度: >98%
  • 溶解度: DMSO: 83.33 mg/mL (197.80 mM)
  • 储存: Store at -20°C
  • 库存: 现货

Background

MD2-TLR4-IN-1 (Compound 22m) is a potent inhibitor of myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4). MD2-TLR4-IN-1 (compound 22m) inhibits lipopolysaccharide (LPS)-induced expression of tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) in macrophages with IC50 of 0.89 μM and 0.53 μM, respectively.


[1] Zhiguo Liu, et al. J Med Chem. 2019 Jun 13;62(11):5453-5469.

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