ML367

ML367 is a potent, micromolar inhibitor of ATPase family AAA domain-containing protein 5 (ATAD5) stabilization. ML367 blocks DNA repair pathways and general DNA damage responses including RPA32-phosphorylation and CHK1-phosphorylation in response to UV ir

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5mg

￥2725.00

2180.00

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10mg

￥4500.00

3600.00

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50mg

￥2725.00

2180.00

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100mg

￥4850.00

3880.00

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200mg

￥0.00

0.00

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500mg

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0.00

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Background

ML367 is a probe molecule found to block general DNA damage responses including RPA32-phosphorylation and CHK1-phosphorylation in response to UV irradiation. In this regard, the probe molecule could block DNA repair pathways that function upstream of ATAD5. Additionally, ML367 sensitizes cells possessing a knock-out mutation of the PARP1 gene and as a result may serve as a sensitizer to kill cancer cells defective in the poly (ADP-ribose) polymerase 1 (PARP1)-dependent DNA repair pathway.[1]

[1] Jason M. Rohde, et al. Probe Reports from the NIH Molecular Libraries Program. Bethesda: National Center for Biotechnology Information (US); 2010–.