MMAF-OMe

MMAF-Ome 是 ADC 的一部分，能够抑制 MDAMB435/5T4，MDAMB361DYT2，MDAMB468 和 Raji (5T4-) 这四种肿瘤细胞， IC50 值分别为 0.056 nM，0.166 nM，0.183 nM 和 0.449 nM。

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库存: 现货

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数量
2mg

￥450.00

360.00

- +
5mg

￥725.00

580.00

- +
10mg

￥1150.00

920.00

- +
50mg

￥0.00

0.00

- +
100mg

￥0.00

0.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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货号: ajce57510
CAS: 863971-12-4
别名: Monomethyl auristatin F methyl ester
分子式: C40H67N5O8
分子量: 745.99
纯度: >98%
溶解度: DMSO: ≥ 100 mg/mL (134.05 mM)
储存: Store at -20°C,unstable in solution, ready to use.
库存: 现货

Background

MMAF-Ome belongs to ADC, and inhibits several tumor cell lines with IC50s of 0.056 nM, 0.166 nM, 0.183 nM, and 0.449 nM for MDAMB435/5T4, MDAMB361DYT2, MDAMB468, and Raji (5T4-) cell lines, respectively.

2.5F-Fc and 2.5F-Fc-MMAF have similar IC50 values (6.9±1.1 vs. 8.3±1.3 nM, respectively), indicating that MMAF conjugation has negligible impact on integrin-binding affinity[1].

[1]. Currier NV, et al. Targeted Drug Delivery with an Integrin-Binding Knottin-Fc-MMAF Conjugate Produced by Cell-Free Protein Synthesis. Mol Cancer Ther. 2016 Jun;15(6):1291-300.