N6,N6-Dimethyladenosine

A modified nucleoside

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50mg

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Background

N⁶,N⁶-Dimethyladenosine is a modified nucleoside.¹ It has been found in tRNA isolated from M. bovis. Dimethylation of adjacent adenosine nucleosides (m⁶₂Am⁶₂A) is found in E. coli 16S rRNA and is important for the initiation of protein synthesis.² N⁶,N⁶-Dimethyladenosine inhibits the proliferation of L1210 leukemia cells in vitro (IC₅₀ = 0.5 ?g/ml) but does not have antitumor activity in vivo.² It is also a component of the antibiotic and protein synthesis inhibitor puromycin .

1.Chan, C.T.Y., Chionh, Y.H., Ho, C.-H., et al.Identification of N6,N6-dimethyladenosine in transfer RNA from Mycobacterium bovis Bacille Calmette-GuérinMolecules16(6)5168-5181(2011) 2.Poldermans, B., Van Buul, C.P.J.J., and Van Knippenberg, P.H.Studies on the function of two adjacent N6,N6-dimethyladenosines near the 3' end of 16 S ribosomal RNA of Escherichia coli. II. The effect of the absence of the methyl groups on initiation of protein biosynthesisJ. Biol. Chem.254(18)9090-9093(1979)